ANTIMICROBIAL AGENT

Ramore-Fighson possesses multi-antimicrobial actions. It inhibits the dihydropteroate synthetase (DHPS). Its cyclic amide constituent inhibits cell wall biosynthesis in bacteria and fungi; it impairs the integrity of their plasma membranous entrance into the cytoplasm, resulting in leakage of cell contents and cell death. Ramore-Fighson inhibits the topoisomerase II ligase domain, leaving the two nuclease domains intact. This modification, coupled with the constant action of the topoisomerase II in the bacterial cell, leads to DNA fragmentation via the nucleasic activity of the intact enzyme domains.

Brown Caplet

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